Escin, Hydroxyethylrutoside, and Daflon: Comparing 3 Medical Treatments for Chronic Venous Insufficiency

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There are several beneficial medical treatments available for managing chronic venous insufficiency (CVI). In this article, we will provide an overview of three major therapies - escin, hydroxyethylrutoside, and Daflon.

These three treatments can provide significant relief from CVI symptoms like pain, aching, swelling, heaviness, and leg cramps when used consistently. They work through complementary mechanisms to improve venous tone, reduce inflammation, decrease capillary permeability, and enhance lymphatic. 

This article explores how these treatments work and how to go about their use in CVI management.

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What are the three treatments for chronic venous insufficiency involving escin, hydroxyethylrutoside, and Daflon?


Escin is a mixture of triterpene saponins extracted from the seeds of the horse chestnut tree. The main active component is aescin. 

According to a review of escin's properties based on articles identified via an initial search of PubMed, escin has specific anti-inflammatory properties in reducing vascular permeability in inflamed tissues, thereby inhibiting edema formation. It also has potential anti-oxidative effects. 

As per our experience at the Vein Center Doctor, escin works as an anti-inflammatory and vein tonic that can help treat chronic venous insufficiency. It helps improve venous tone, which refers to the contractility of veins to pump blood. It also helps reduce edema or swelling by supporting healthy fluid drainage.


Hydroxyethylrutoside is a flavonoid compound that has antioxidant and anti-inflammatory properties. A multicenter, double-blind, randomized, placebo-controlled trial studied the efficacy and tolerability of hydroxyethylrutosides in elderly patients with chronic venous insufficiency or varicose veins. 

The study found that the hydroxyethylrutoside-treated group showed a significantly greater reduction in total symptom scores than the placebo group. Based on our experience, it can be an effective treatment for reducing capillary leakage and edema in chronic venous insufficiency

Hydroxyethylrutoside helps stabilize and strengthen the walls of veins and tiny capillaries, reducing permeability and leakage of fluid into surrounding tissue. This helps manage leg swelling and edema.


Daflon contains 90% purified micronized diosmin and 10% hesperidin, both citrus flavonoids. According to a study on the efficacy of Daflon 500 mg in chronic venous insufficiency, it helps improve venous tone and lymphatic drainage while reducing inflammation. 

Diosmin and hesperidin work synergistically to enhance venous and lymphatic circulation. This promotes the proper return of blood to the heart. Daflon also helps protect vascular endothelial cells and prevents capillary leakage.

Comparing the Three Treatments

TreatmentDosageFormsDuration for ReliefEfficacy for SymptomsSide EffectsCost and Availability
Escin50-150mg, 2-3 times per dayTablets or capsules2-4 weeksReduces aching, tiredness, heaviness, and swelling in the legsWell-tolerated, stomach upset may occasionally occurAffordable, over-the-counter supplement
Hydroxyethylrutoside500-1000mg per dayOral tablets or powders1-2 weeks for initial effects, 4-6 weeks for full benefitReduces capillary leakage, edema, and stubborn edemaWell-toleratedAffordable, over-the-counter supplement
Daflon1000mg per day (500mg twice daily)Tablets2-4 weeksImproves venous tone, lymphatic drainage, and reduces inflammationWell-tolerated, may cause headaches or dizziness in some peoplePrescription-only, more expe

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While more research is still needed to confirm their long-term efficacy and safety, these three treatments offer hope for dramatically improving quality of life. Managing chronic venous insufficiency requires an integrated approach with medical treatment, lifestyle changes, and a focus on overall vascular health based on the Vein Center Doctor’s experience.

If you are suffering from chronic venous insufficiency symptoms like pain, fatigue, swelling, restlessness, cramps, or ulcers in the legs, the expert vein doctors at Vein Center Doctor can help. We offer advanced diagnosis and minimally invasive treatments to address the underlying venous issues causing your symptoms. 

Reach out now to get on the schedule - our knowledgeable vein specialists are standing by to assist you.

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